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Home » Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Combo

Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Combo

October 22, 2025 by Maria Leave a Comment


Introduction

Can’t decide between juicy meatloaf and creamy mac and cheese? Why not have both! The Mac and Cheese Meatloaf Casserole is a hearty, cheesy, all-in-one dinner that blends two comfort classics into one unforgettable dish. 🧡

This recipe features a tender, savory meatloaf base topped with rich, gooey macaroni and cheese, then baked to golden perfection. It’s cozy, family-friendly, and perfect for weekends, potlucks, or when you want to impress with comfort food at its finest.

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Ingredients List

For the Meatloaf Base:

  • 1 ½ lbs ground beef (or a mix of beef and pork)
  • 1 cup breadcrumbs
  • ½ cup milk
  • 2 eggs
  • ½ onion, finely chopped
  • 3 cloves garlic, minced
  • ½ cup ketchup (plus 2 tablespoons for topping)
  • 1 tablespoon Worcestershire sauce
  • 1 teaspoon salt
  • ½ teaspoon black pepper
  • ½ teaspoon smoked paprika

For the Mac and Cheese Layer:

  • 8 oz (225g) elbow macaroni
  • 2 tablespoons butter
  • 2 tablespoons all-purpose flour
  • 2 cups milk
  • 2 cups shredded cheddar cheese (plus extra for topping)
  • ½ teaspoon salt
  • ¼ teaspoon black pepper
  • ¼ teaspoon mustard powder (optional)

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Timing

  • Prep Time: 20 minutes
  • Cook Time: 45 minutes
  • Total Time: ~1 hour 5 minutes

Step-by-Step Instructions

Step 1: Prepare the Meatloaf

Preheat oven to 375°F (190°C).
In a large bowl, combine ground beef, breadcrumbs, milk, eggs, onion, garlic, ketchup, Worcestershire sauce, salt, pepper, and smoked paprika. Mix until just combined — don’t overwork the meat.

Press the mixture evenly into a greased 9×13-inch baking dish. Bake for 25 minutes. Drain any excess fat if needed.

Step 2: Make the Mac and Cheese

While the meatloaf bakes, cook macaroni according to package directions; drain.
In a saucepan, melt butter over medium heat. Add flour and whisk for 1 minute. Slowly whisk in milk and cook until thickened (3–5 minutes). Stir in salt, pepper, and mustard powder.
Remove from heat and add cheese, stirring until melted. Combine the sauce with cooked macaroni.

Step 3: Assemble the Casserole

Remove the meatloaf from the oven and spread 2 tablespoons of ketchup over the top (optional).
Spoon the mac and cheese evenly over the meatloaf layer. Sprinkle with extra cheddar cheese.

Step 4: Bake

Return to the oven and bake uncovered for 15–20 minutes, until bubbly and golden brown.

Step 5: Serve

Let rest for 10 minutes before slicing. Garnish with chopped parsley if desired.


Nutritional Information (Per Serving)

  • Calories: 560 kcal
  • Protein: 36g
  • Carbohydrates: 28g
  • Fat: 34g
  • Fiber: 2g
  • Calcium: 30% DV

Healthier Alternatives

  • Use lean ground turkey or chicken instead of beef.
  • Substitute whole wheat pasta for added fiber.
  • Swap some cheese for Greek yogurt for creaminess with fewer calories.
  • Add finely chopped spinach or zucchini to the meatloaf for hidden veggies.

Serving Suggestions

  • Serve with steamed broccoli, roasted carrots, or a fresh green salad.
  • Drizzle with BBQ sauce for a smoky twist.
  • Pair with garlic bread or buttered rolls for the ultimate comfort meal.

Common Mistakes to Avoid

  1. Overmixing the meat: It can make the meatloaf tough — mix gently.
  2. Undercooking the pasta: Keep it slightly firm since it will bake again.
  3. Adding too much cheese on top: It can create a greasy layer — just enough for golden color.
  4. Skipping rest time: Letting it cool slightly makes slicing easier and cleaner.

Storing Tips

  • Refrigerate: Keeps for up to 4 days in an airtight container.
  • Freeze: Wrap individual portions and freeze for up to 2 months.
  • Reheat: Warm in the oven at 350°F (175°C) for 15 minutes or microwave gently.

Conclusion

The Mac and Cheese Meatloaf Casserole is pure comfort food heaven — rich, cheesy, and satisfyingly hearty. 🧀🍖 Whether you’re feeding a crowd or treating yourself, this dish delivers the best of both worlds: creamy mac and cheese meets classic meatloaf.

One bite, and you’ll understand why this recipe is a weeknight winner and a family favorite!

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